Bisphenol A (BPA) is an endocrine disrupting environmental contaminant used in a wide variety of products, and BPA metabolites are found in almost everyone’s urine, suggesting widespread exposure from multiple sources. Regulatory agencies estimate that virtually all BPA exposure is from food and beverage packaging. However, free BPA is applied to the outer layer of thermal receipt paper present in very high (∼20 mg BPA/g paper) quantities as a print developer. Not taken into account when considering thermal paper as a source of BPA exposure is that some commonly used hand sanitizers, as well as other skin care products, contain mixtures of dermal penetration enhancing chemicals that can increase by up to 100 fold the dermal absorption of lipophilic compounds such as BPA. We found that when men and women held thermal receipt paper immediately after using a hand sanitizer with penetration enhancing chemicals, significant free BPA was transferred to their hands and then to French fries that were eaten, and the combination of dermal and oral BPA absorption led to a rapid and dramatic average maximum increase (Cmax) in unconjugated (bioactive) BPA of ∼7 ng/mL in serum and ∼20 µg total BPA/g creatinine in urine within 90 min. The default method used by regulatory agencies to test for hazards posed by chemicals is intra-gastric gavage. For BPA this approach results in less than 1% of the administered dose being bioavailable in blood. It also ignores dermal absorption as well as sublingual absorption in the mouth that both bypass first-pass liver metabolism. The elevated levels of BPA that we observed due to holding thermal paper after using a product containing dermal penetration enhancing chemicals have been related to an increased risk for a wide range of developmental abnormalities as well as diseases in adults.
Bisphenol A (BPA), which is used in the manufacture of plastic food containers and refillable drinks bottles, dysregulates authophagy-regulated lipid metabolism in hepatocytes, according to new research published in Endocrinology.
Bisphenol A, commonly known as BPA, is the great unknown threat to western civilization. More dangerous than demographic shifts, Islam, or even the dreaded THOT, it is set to become the most important political issue of our age. At over 6 billion pounds produced per year it is most ubiquitous plasticizer used on earth. It’s xenoestrogens find their way into your body from the of plastic products you use every day. Bisphenol A is in everything, from your plastic bottle of glistening filtered spring water, to the catheter you’ll use once the toxins from BPA turn cells in your prostate cancerous. Did someone hand you a receipt today? Hopefully you had not recently sterilized your hands with that little bottle of congealed rubbing alcohol you have in the car. Ten thousand times more BPA just leeched into your bloodstream because you used hand sanitizer before touching that thermal paper receipt. If that wasn’t already enough, just remember that it’s in your kid’s milk bottle, your toothbrush, your dental implants and fillings, and your Tupperware lunch container that you microwaved earlier. Bisphenol A is It is the cause of your depression, your low T, your man tits. BPA will be the downfall of civilization that no one sees coming.